Doctors are well aware of possible drug interactions Generic Aripiprazole and may probably be monitoring you closely for them. Don't change your daily dose or stop taking the drug altogether without first consulting them. There are several drugs that should not be taken with Aripiprazole medication since severe interactions have been known to occur.

. Sibultramine; - in case you are on this medication for another ailment, inform your pharmacist or doctor before you start taking Aripiprazole.

. Carbamazephine (Tegrol); - this can drastically decrease Aripiprazole levels in the body by increasing the speed at which body enzymes such as CYP3A4, a liver enzyme, degrades it. Manufacturers recommend that patients taking Carbamazepine should take double doses of Aripiprazole under direction of their doctor to compensate for the resulting shortfall. Other drugs that are likely to have the same effect include phenytoin (Dilantin), Phenobarbital and rifampin (Rifamate, Rifadin, Rifater and Rimactane).

. Ketoconazal (Nizoral); - this drug decreases the activity of CYP3A4 and therefore increases the Aripiprazole levels in the body. Manufacturers recommend that the Aripiprazole daily dose be reduced by half if the patient is also undergoing ketoconazole therapy. Other drugs that inhibit CYP3A4 can also result in high Aripiprazole levels in the body but the magnitude of their effects is yet to be clinically studied. These drugs include; indinavir (Crxivan, saquinavir (Invirase), ritonavir (Norvir), nelfinavir (Viracept), itraconazole (Sporanox), voriconaole (Vfend), fluconazole (Diflucan), verpamil (Isoptin, Calan), diltiazem (Dilacor, Cardizem), cimetidine (Tagamet), nefazodone (Serzone), clarithromycin (Biaxin) and erythromycin.

. Quinidine (Quinidex, Quinaglute); - this drug inhibits CYP2D6, another enzyme in the liver that degrades Aripiprazole. Suppression of this enzyme's activities therefore results in higher levels of Aripiprazole in the body. Manufacturers recommend the daily Aripiprazole dose should be reduced by a half if the patient is undergoing quinidine therapy. Other drugs that inhibit CYP2D6 include paroxetine (Paxil and fluoxetine (Prozac)

. Alpha-one receptor inhibitors such as terazosin (Hytrin), prazosin (Minipress and doxazosin (Cardura) used to control blood pressure and for prostatic enlargement can also increase the chances of hypotension (severely reduced blood pressure) occurring when taken during Aripiprazole therapy.

. Some drugs increase the risk of seizures by reducing the seizure threshold when used together with Aripiprazole. These include bupropion, phenothiazides such as thiodazine, isoniazid (INH), tramadol, theophylline and tricyclic antidepressants such as amitriptyline.

It is important to check labels of all cold and cough drugs since most of them contain ingredients that can cause drowsiness. Not all drug interactions have been listed in this document. You should therefore ask the doctor how safe it is to use a drug before you take it. To be safe, always have a list of medicines that have adverse interactions with Aripiprazole so that you can share it with your new physician or pharmacist. Non prescription herbal products also pose a threat since the chemical composition of most of them has not been determined. There is no telling what effects they have on the body that may interfere with Aripiprazole levels in the body or even how aripiprazole functions.